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Methaqualone, or brand name Quaalude, is a central nervous system depressant that acts as a sedative and hypnotic. Its effects include drowsiness, and reduced heart rate and respiration


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Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system. When GABA activity is increased, blood pressure drops and the breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia. Methaqualone peaks in the bloodstream within several hours, with a half-life of 20–60 hours. Regular users build up a physical tolerance, requiring larger doses for the same effect. Overdose can lead to nervous system shutdown, coma and death. Methaqualone is not recommended for use while pregnant and is in pregnancy.


In prescribed doses, Quaaludes promotes relaxation, sleepiness and sometimes a feeling of euphoria. It causes a drop in blood pressure and slows the pulse rate. These properties are the reason why it was initially thought to be a useful sedative and anxiolytic.

Quaaludes should not be taken with alcohol or with other central nervous system depressants. This increases the depressant effects and depending on the doses taken it can be fatal.
Do not drive or operate machinery while taking Quaaludes.
Quaaludes are not recommended during pregnancy as the effects on human fetal development are not clear.

Side effects

  •  Dizziness,
  • nausea,
  • vomiting,
  • diarrhea,
  • abdominal cramps,
  • fatigue,
  • itching,
  •  tingling sensation in arms and legs,
  • seizures

Note that the depressant effects of quaaludes may include reduced heart rate and respiration.

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